Components of the anti-Mullerian hormone signaling pathway in gonads

被引：87

作者：

di Clemente, N ^{[1
]}

Josso, N ^{[1
]}

Gouédard, L ^{[1
]}

Belville, C ^{[1
]}

机构：

[1] INSERM, Unite 493, F-92140 Clamart, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2003年 / 211卷 / 1-2期

关键词：

anti-Mullerian hormone; Mullerian inhibiting substance; anti-Mullerian hormone type II receptor; activin receptor-like kinase; signaling pathway; gonads;

D O I：

10.1016/j.mce.2003.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Anti-Mullerian hormone (AMH) is a member of the Transforming Growth Factor-beta (TGF-beta) family implicated in the regression of Mullerian ducts in male fetuses and in the development and function of gonads of both sexes. Members of the TGF-beta family signal through two types of serine/threonine kinase receptors called type I and type II, and two types of Smad proteins, receptor-regulated Smad (R-Smad) and common Smad, Smad4. Components of the AMH signaling pathway have been identified in gonads and gonadal cell lines. The AMH type II receptor is highly specific. In contrast, the identity of the AMH type I receptor is not clear; three type I receptors of Bone Morphogenetic Proteins (BMPs), Alk2, Alk3 and Alk6 may transduce AMH signals, but none of them has all the characteristics of an AMH type I receptor. AMH activates BMP-specific R-Smads and reporter genes. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：9 / 14

页数：6

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