Methylated DNA as a possible screening marker for neoplastic disease in several body fluids

被引：39

作者：

Müller, HM ^{[1
]}

Widschwendter, M ^{[1
]}

机构：

[1] Univ Innsbruck Hosp, Dept Obstet & Gynecol, A-6020 Innsbruck, Austria

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2003年 / 3卷 / 04期

关键词：

body fluid; DNA methylation; early detection; free DNA; neoplasia; plasma; screening marker; serum;

D O I：

10.1586/14737159.3.4.443

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Early detection appears to be one of the most important approaches to reducing mortality caused by neoplasia. Changes in DNA methylation have been recognized as one of the most common molecular alterations in human tumors. Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease.

引用

页码：443 / 458

页数：16

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