Modulating gut microbiota as an anti-diabetic mechanism of berberine

被引：133

作者：

Han, Junling ^{[1
]}

Lin, Huiling ^{[1
]}

Huang, Weiping ^{[1
]}

机构：

[1] 187th Hosp PLA, Dept Endocrinol & Metab, Haikou, Peoples R China

来源：

MEDICAL SCIENCE MONITOR | 2011年 / 17卷 / 07期

关键词：

berberine; diabetes mellitus; gut microbiota; INDUCED DIABETIC-RATS; ESCHERICHIA-COLI; INTESTINAL DISACCHARIDASES; VIBRIO-CHOLERAE; METABOLISM; OBESITY; NORFLOXACIN; EXPRESSION; DISORDERS; THERAPY;

D O I：

10.12659/MSM.881842

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies. However, the mechanism of berberine's antidiabetic effect has not yet been well explained. Recent evidence suggests that the gut microbiota composition is associated with obesity and type 2 diabetes, which are closely associated with a low-grade inflammatory state. The protective effect against diabetes of gut microbiota modulation with probiotics or antibiotics has been confirmed in recent observations. Berberine has significant antimicrobial activity against several microbes through inhibiting the assembly function of FtsZ and halting the bacteria cell division. Because berberine acts topically in the gastrointestinal tract and it is poorly absorbed, berberine might modulate gut microbiota without systemic anti-infective activity. Our hypothesis is that gut microbiota modulation may be one mechanism of the antidiabetic effect of berberine. Our hypothesis may provide a novel explanation for berberine's therapeutic effect in patients with diabetes mellitus.

引用

页码：RA164 / RA167

页数：4

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