Chitosan microspheres prepared by an aqueous process: Release of indomethacin

被引：20

作者：

Aggarwal, A ^{[1
]}

Kaur, S ^{[1
]}

Tiwary, AK ^{[1
]}

Gupta, S ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

来源：

JOURNAL OF MICROENCAPSULATION | 2001年 / 18卷 / 06期

关键词：

microspheres; chitosan; indomethacin;

D O I：

10.1080/02652040110065495

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chitosan microspheres loaded with indomethacin were prepared using only aqueous solvents. The influence of formulation variables on indomethacin content in the microspheres and time for release of 66.6% of indomethacin from the microspheres was investigated. Amongst various variables, the indoemthacin: chitosan ratio and amount of crosslinking agent were important. Response surfaces were generated to optimise the aqueous process with respect to these critical variables, in order to obtain maximum indomethacin loading and optimum t(66.6).

引用

页码：819 / 823

页数：5

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