Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

被引：3966

作者：

Lesch, KP

Bengel, D

Heils, A

Sabol, SZ

Greenberg, BD

Petri, S

Benjamin, J

Muller, CR

Hamer, DH

Murphy, DL

机构：

[1] NIMH,CLIN SCI LAB,NIH,BETHESDA,MD 20892

[2] NCI,BIOCHEM LAB,NIH,BETHESDA,MD 20892

[3] UNIV WURZBURG,INST HUMAN GENET,D-97074 WURZBURG,GERMANY

来源：

SCIENCE | 1996年 / 274卷 / 5292期

关键词：

D O I：

10.1126/science.274.5292.1527

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and 5-HT uptake in lymphoblasts. Association studies in two independent samples totaling 505 individuals revealed that the 5-HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in anxiety-related personality traits in individuals as well as sibships.

引用

页码：1527 / 1531

页数：5

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