A model of canine leukocyte telomere dynamics

被引：35

作者：

Benetos, Athanase ^{[2
,3
]}

Kimura, Masayuki

Labat, Carlos ^{[3
]}

Buchoff, Gerald M. ^{[4
]}

Huber, Shell ^{[4
]}

Labat, Laura ^{[5
]}

Lu, Xiaobin

Aviv, Abraham ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Ctr Human Dev & Aging, MSB, Newark, NJ 07103 USA

[2] Nancy Univ Hosp, Geriatr Serv, F-54511 Nancy, France

[3] Nancy Univ, Fac Med, INSERM, U961, F-54500 Nancy, France

[4] Hollist Pet Care, Little Falls, NJ 07424 USA

[5] Ecole Natl Vet Alfort, F-94704 Maisons Alfort, France

来源：

AGING CELL | 2011年 / 10卷 / 06期

关键词：

aging; skeletal muscle; telomere; life span; longevity; mammals;

D O I：

10.1111/j.1474-9726.2011.00744.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have found associations of leukocyte telomere length (TL) with diseases of aging and with longevity. However, it is unknown whether birth leukocyte TL or its age-dependent attrition the two factors that determine leukocyte TL dynamics explains these associations because acquiring this information entails monitoring individuals over their entire life course. We tested in dogs a model of leukocyte TL dynamics, based on the following premises: (i) TL is synchronized among somatic tissues; (ii) TL in skeletal muscle, which is largely postmitotic, is a measure of TL in early development; and (iii) the difference between TL in leukocytes and muscle (?LMTL) is the extent of leukocyte TL shortening since early development. Using this model, we observed in 83 dogs (ages, 442 months) no significant change with age in TLs of skeletal muscle and a shorter TL in leukocytes than in skeletal muscle (P < 0.0001). Age explained 43% of the variation in ?LMTL (P < 0.00001), but only 6% of the variation in leukocyte TL (P = 0.035) among dogs. Accordingly, muscle TL and ?LMTL provide the two essential factors of leukocyte TL dynamics in the individual dog. When applied to humans, the partition of the contribution of leukocyte TL during early development vs. telomere shortening afterward might provide information about whether the individuals longevity is calibrated to either one or both factors that define leukocyte TL dynamics.

引用

页码：991 / 995

页数：5

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