Diet and cancer prevention:: the roles of observation and experimentation

被引：68

作者：

Martinez, Maria Elena ^{[1
,2
]}

Marshall, James R. ^{[3
]}

Giovannucci, Edward ^{[4
,5
,6
,7
]}

机构：

[1] Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA

[2] Univ Arizona, Mel & Enid Zuckerman Arizona Coll Publ Hlth, Tucson, AZ 85724 USA

[3] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 09期

关键词：

D O I：

10.1038/nrc2441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Observational epidemiology and experimentation by randomized controlled trials (RCTs) have been used to evaluate dietary factors in cancer prevention; however, consistency in findings has been elusive. In several circles, RCTs are viewed as more credible than observational studies. As the testing of dietary epidemiological findings in RCTs has been more common for colorectal cancer than for other cancers, we use experience with this malignancy to critically appraise the reasons for discrepancies between results of observational and experimental studies.

引用

页码：694 / 703

页数：10

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