Inhibitory effect of cyclic terpenes (limonene, menthol, menthone and thymol) on Fusarium verticillioides MRC 826 growth and fumonisin B1 biosynthesis

被引：122

作者：

Dambolena, J. S. ^{[2
]}

Lopez, A. G. ^{[3
]}

Canepa, M. C. ^{[1
]}

Theumer, M. G. ^{[1
]}

Zygadlo, J. A. ^{[2
]}

Rubinstein, H. R. ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Bioquim Clin, CIBICI,CONICET, RA-5000 Cordoba, Argentina

[2] Univ Nacl Cordoba, Fac Ciencias Exactas Fis & Nat, Catedra Quim Organ, IMBIV CONICET, RA-5000 Cordoba, Argentina

[3] Univ Nacl Cordoba, Fac Ciencias Exactas Fis & Nat, Inst Ciencia & Tecnol Alimentos, RA-5000 Cordoba, Argentina

来源：

TOXICON | 2008年 / 51卷 / 01期

关键词：

cyclic terpenes; Fusarium verticillioides; fumonisin B1; maize; toxicogenesis;

D O I：

10.1016/j.toxicon.2007.07.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The minimum inhibitory concentration (MIC) of cyclic terpenes (limonene, menthol, menthone and thymol) against Fusarium verticillioides MRC 826 was assessed by using the semisolid agar antifungal susceptibility (SAAS) technique. Limonene, menthol, menthone and thymol were evaluated at final concentrations of 25, 50, 75, 150, 200, 250, 500 and 1000 mu L/L of culture medium. Limonene and thymol showed the highest inhibitory effects on F. verticillioides development. Thus, the effects of monoterpenes on fumonisin B1 (FB1) biosynthesis were evaluated by using corn grain (Zea mays) as substrate. The monoterpenes were inserted on maize I day before inoculation with a conidial suspension of E verticillioides to give final concentrations of 75 ppm. At this concentration, thymol was the most active inhibitor on FB1 biosynthesis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：37 / 44

页数：8

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