Visualisation and quantification of rates of atrophy in Alzheimer's disease

被引:285
作者
Fox, NC
Freeborough, PA
Rossor, MN
机构
[1] NATL HOSP NEUROL & NEUROSURG,DEMENTIA RES GRP,LONDON WC1N 3BG,ENGLAND
[2] ST MARYS HOSP,IMPERIAL COLL,SCH MED,LONDON,ENGLAND
关键词
D O I
10.1016/S0140-6736(96)05228-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Definitive diagnosis of Alzheimer's disease requires histological examination of brain tissue. In life, brain atrophy can be visualised by computed tomography or magnetic resonance (MR) imaging, but the atrophy due to the disease is difficult to distinguish from that caused by normal ageing. We have investigated use of accurate positional matching (registration) and digital subtraction of serially acquired MR brain scans to allow determination of rates of global and regional atrophy. Methods This technique was applied to eleven patients with clinically diagnosed Alzheimer's disease and eleven age-matched controls. Each individual had two scans approximately 1 year apart; scan intervals were matched between the groups. Findings The median rate atrophy was significantly greater in the Alzheimer's disease group than in the control group (12 . 3 [range 5 . 8 to 23 . 6] vs 0 . 3 (-1 . 2 to 1 . 7) mL per year; p<0 . 0001). There was no overlap between the groups. Furthermore, three non-demented individuals at risk of familiar Alzheimer's disease had scans 6-14 months apart and showed greater rates of volume loss than the controls; these three individuals have subsequently developed symptoms. Interpretation This technique may be useful for the diagnosis of Alzheimer's disease, the assessment of disease progression, and the evaluation of potential treatments.
引用
收藏
页码:94 / 97
页数:4
相关论文
共 26 条
[1]   HIPPOCAMPAL VOLUME LOSSES IN MINIMALLY IMPAIRED ELDERLY [J].
CONVIT, A ;
DELEON, MJ ;
TARSHISH, C ;
DESANTI, S ;
KLUGER, A ;
RUSINEK, H ;
GEORGE, AE .
LANCET, 1995, 345 (8944) :266-266
[2]  
Convit Antonio, 1993, Psychiatric Quarterly (New York), V64, P371, DOI 10.1007/BF01064929
[3]   THE CERAD EXPERIENCE .8. NEUROIMAGING NEUROPATHOLOGY CORRELATES OF TEMPORAL-LOBE CHANGES IN ALZHEIMERS-DISEASE [J].
DAVIS, PC ;
GEARING, M ;
GRAY, L ;
MIRRA, SS ;
MORRIS, JC ;
EDLAND, SD ;
LIN, T ;
HEYMAN, A .
NEUROLOGY, 1995, 45 (01) :178-179
[4]   THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD) .3. RELIABILITY OF A STANDARDIZED MRI EVALUATION OF ALZHEIMERS-DISEASE [J].
DAVIS, PC ;
GRAY, L ;
ALBERT, M ;
WILKINSON, W ;
HUGHES, J ;
HEYMAN, A ;
GADO, M ;
KUMAR, AJ ;
DESTIAN, S ;
LEE, C ;
DUVALL, E ;
KIDO, D ;
NELSON, MJ ;
BELLO, J ;
WEATHERS, S ;
JOLESZ, F ;
KIKINIS, R ;
BROOKS, M .
NEUROLOGY, 1992, 42 (09) :1676-1680
[5]   CRITICAL ANALYSIS OF THE USE OF COMPUTER-ASSISTED TRANSVERSE AXIAL-TOMOGRAPHY TO STUDY HUMAN BRAIN IN AGING AND DEMENTIA OF THE ALZHEIMER TYPE [J].
DECARLI, C ;
KAYE, JA ;
HORWITZ, B ;
RAPOPORT, SI .
NEUROLOGY, 1990, 40 (06) :872-883
[6]   DISCRIMINANT-ANALYSIS OF MRI MEASURES AS A METHOD TO DETERMINE THE PRESENCE OF DEMENTIA OF THE ALZHEIMER-TYPE [J].
DECARLI, C ;
MURPHY, DGM ;
MCINTOSH, AR ;
TEICHBERG, D ;
SCHAPIRO, MB ;
HORWITZ, B .
PSYCHIATRY RESEARCH, 1995, 57 (02) :119-130
[7]   ALZHEIMERS-DISEASE - LONGITUDINAL CT STUDIES OF VENTRICULAR CHANGE [J].
DELEON, MJ ;
GEORGE, AE ;
REISBERG, B ;
FERRIS, SH ;
KLUGER, A ;
STYLOPOULOS, LA ;
MILLER, JD ;
LAREGINA, ME ;
CHEN, C ;
COHEN, J .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1989, 152 (06) :1257-1262
[8]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[9]   Atrophy of the hippocampal formation in early familial Alzheimer's disease a longitudinal MRI study of at-risk members of a family with an amyloid precursor protein 717(VAL-GLY) mutation [J].
Fox, NC ;
Warrington, EK ;
Stevens, JM ;
Rossor, MN .
NEUROBIOLOGY OF ALZHEIMER'S DISEASE, 1996, 777 :226-232
[10]  
FOX NC, 1996, P INT SOC MAGNETIC R, V1, P234