Defective autophagy leads to cancer

被引：234

作者：

Edinger, AL ^{[1
]}

Thompson, CB ^{[1
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

CANCER CELL | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1535-6108(03)00306-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cellular proteins are degraded within two distinct compartments: the proteasome and the lysosome. Alterations in proteasomal degradation can contribute to carcinogenesis. In contrast, alterations in autophagic protein degradation through the lysosome have not been linked to cancer. Now two reports demonstrate that the autophagic gene, Beclin 1, is a haploinsufficient tumor suppressor gene. These new data suggest that autophagic degradation provides an important mechanism to prevent cellular transformation.

引用

页码：422 / 424

页数：3

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