Immune control of HSV-1 latency

被引：60

作者：

Decman, V

Freeman, ML

Kinchington, PR

Hendricks, RL

机构：

[1] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Grad Program Immunol, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Grad Program Mol Virol & Microbiol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15213 USA

来源：

VIRAL IMMUNOLOGY | 2005年 / 18卷 / 03期

关键词：

D O I：

10.1089/vim.2005.18.466

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent infection in sensory neurons that persists for the life of the individual. Reactivation of these latent viral genomes with virion formation is the source of virus for most HSV recurrent disease. This review details recent exciting findings supporting a role for the host immune system, particularly CD8+ T cells in maintaining HSV-1 in a latent state.

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页码：466 / 473

页数：8

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