Ketolide treatment of Haemophilus influenzae experimental pneumonia

被引：27

作者：

Piper, KE ^{[1
]}

Rouse, MS ^{[1
]}

Steckelberg, JM ^{[1
]}

Wilson, WR ^{[1
]}

Patel, R ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Dept Internal Med, Div Infect Dis, Rochester, MN 55902 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期

关键词：

D O I：

10.1128/AAC.43.3.708

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 mu g/ml, respectively, Both HMR 3004 and HMR 3647 mere active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or BMR 3647 in this model.

引用

页码：708 / 710

页数：3

共 13 条

[1] Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens [J].

Agouridas, C ;

Bonnefoy, A ;

Chantot, JF .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) :2149-2158

[2]

AGOURIDAS C, 1996, 3 INT C MACR AZ STRE, P97

[3] In vitro activities of the ketolide HMR 3647 against recent gram-positive clinical isolates and Haemophilus influenzae [J].

Barry, AL ;

Fuchs, PC ;

Brown, SD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (08) :2138-2140

[4] In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae [J].

Barry, AL ;

Fuchs, PC ;

Brown, SD .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1997, 16 (10) :767-769

[5] Comparative antimicrobial activity and kill-curve investigations of novel ketolide antimicrobial agents (HMR 3004 and HMR 3647) tested against Haemophilus influenzae and Moraxella catarrhalis strains [J].

Biedenbach, DJ ;

Barrett, MS ;

Jones, RN .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1998, 31 (02) :349-353

[6] Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect [J].

Boswell, FJ ;

Andrews, JM ;

Wise, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (02) :149-153

[7] EXPERIMENTAL PNEUMONIA DUE TO HEMOPHILUS-INFLUENZAE - OBSERVATIONS ON PATHOGENESIS AND TREATMENT [J].

ESPOSITO, AL ;

PENNINGTON, JE .

JOURNAL OF INFECTIOUS DISEASES, 1984, 149 (05) :728-734

[8] In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004 [J].

Jamjian, C ;

Biedenbach, DJ ;

Jones, RN .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) :454-459

[9] A 1994-95 survey of Haemophilus influenzae susceptibility to ten orally administered agents - A 187 clinical laboratory center sample in the United States [J].

Jones, RN ;

Jacobs, MR ;

Washington, JA ;

Pfaller, MA .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1997, 27 (03) :75-83

[10]

*NAT COMM CLIN LAB, 1997, M7A4 NAT COM CLIN LA

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