Pros and cons of inhibiting cholesteryl ester transfer protein

被引：75

作者：

Hirano, K ^{[1
]}

Yamashita, S ^{[1
]}

Matsuzawa, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 565, Japan

来源：

CURRENT OPINION IN LIPIDOLOGY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1097/00041433-200012000-00004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Whether or not it is desirable to inhibit cholesteryl ester transfer protein (CETP) has been an important question for over fifteen years since genetic CETP deficiency was found. Recently, some epidemiological studies which have been reported in Japan as well as Western countries help to clarify the atherogenicity of human subjects with mutations or polymorphisms in the CETP gene, In addition, some experimental atherosclerosis studies, in which CETP was inhibited in rabbits with different approaches, have been reported. There was a considerable difference in the atherogenicity of human CETP deficiency and CETP-inhibited rabbits. In this review, we summarize the recent advances in this field as well as discussing the significance of CETP in reverse cholesterol transport, a major protective system against atherosclerosis. Curr Opin Lipidol 11:589-596 (C)? 2000 Lippincott Williams & Wilkins.

引用

页码：589 / 596

页数：8

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