ATP synthesis driven by proton transport in F1F0-ATP synthase

被引：227

作者：

Weber, J ^{[1
]}

Senior, AE ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Biochem & Biophys, Rochester, NY 14642 USA

来源：

FEBS LETTERS | 2003年 / 545卷 / 01期

关键词：

ATP synthase; subunit rotation; ATP synthesis; ATP hydrolysis; molecular motor; proton transport;

D O I：

10.1016/S0014-5793(03)00394-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：61 / 70

页数：10

共 105 条

[1] STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF F1-ATPASE FROM BOVINE HEART-MITOCHONDRIA [J].

ABRAHAMS, JP ;

LESLIE, AGW ;

LUTTER, R ;

WALKER, JE .

NATURE, 1994, 370 (6491) :621-628

[2] The structure of bovine F-1-ATPase complexed with the peptide antibiotic efrapeptin [J].

Abrahams, JP ;

Buchanan, SK ;

vanRaaij, MJ ;

Fearnley, IM ;

Leslie, AGW ;

Walker, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9420-9424

[3] Stepping rotation of F1-ATPase with one, two, or three altered catalytic sites that bind ATP only slowly [J].

Ariga, T ;

Masaike, T ;

Noji, H ;

Yoshida, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) :24870-24874

[4]

BERKICH DA, 1991, J BIOL CHEM, V266, P123

[5] A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei [J].

Bernstein, BE ;

Williams, DM ;

Bressi, JC ;

Kuhn, P ;

Gelb, MH ;

Blackburn, GM ;

Hol, WGJ .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 279 (05) :1137-1148

[6] The 2.8-Å structure of rat liver F1-ATPase:: Configuration of a critical intermediate in ATP synthesis/hydrolysis [J].

Bianchet, MA ;

Hullihen, J ;

Pedersen, PL ;

Amzel, LM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) :11065-11070

[7] Notes on the mechanism of ATP synthesis [J].

Bianchet, MA ;

Pedersen, PL ;

Amzel, LM .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2000, 32 (05) :517-521

[8] Nanoseconds molecular dynamics simulation of primary mechanical energy transfer steps in F1-ATP synthase [J].

Böckmann, RA ;

Grubmüller, H .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (03) :198-202

[9] Stepwise rotation of the γ-subunit of EF0F1-ATP synthase observed by intramolecular single-molecule fluorescence resonance energy transfer [J].

Börsch, M ;

Diez, M ;

Zimmermann, B ;

Reuter, R ;

Gräber, P .

FEBS LETTERS, 2002, 527 (1-3) :147-152

[10] Catalytic site occupancy during ATP synthase catalysis [J].

Boyer, PD .

FEBS LETTERS, 2002, 512 (1-3) :29-32

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