Does tumour dormancy offer a therapeutic target?

被引：250

作者：

Goss, Paul E. ^{[3
]}

Chambers, Ann F. ^{[1
,2
]}

机构：

[1] Univ Western Ontario, London Reg Canc Program, London, ON N6A 4L6, Canada

[2] Univ Western Ontario, Dept Oncol, London, ON N6A 4L6, Canada

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 12期

关键词：

ADJUVANT TAMOXIFEN THERAPY; MINIMAL RESIDUAL DISEASE; MAMMARY-CARCINOMA CELLS; BREAST-CANCER PATIENTS; RANDOMIZED-TRIAL; BONE-MARROW; METASTATIC OUTGROWTH; POSTMENOPAUSAL WOMEN; PREMENOPAUSAL WOMEN; UPDATED FINDINGS;

D O I：

10.1038/nrc2933

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The increasing number of cancer survivors is cause for celebration, but this expanding population has highlighted the problem of tumour dormancy, which can lead to relapse. As we start to understand more about the biology of dormant cancer cells, we can begin to address how best to treat this form of disease. Preclinical models and initial clinical trials, as exemplified in patients with breast cancer, are paving the way to address how best to treat long-term cancer survivors to minimize the risk of cancer recurrence.

引用

页码：871 / 877

页数：7

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