Chemokines and viruses: friends or foes?

被引：18

作者：

Mahalingam, S

Friedland, JS

Heise, MT

Rulli, NE

Meanger, J

Lidbury, BA

机构：

[1] Univ Wollongong, Dept Biol Sci, Wollongong, NSW 2522, Australia

[2] Imperial Coll Sci Technol & Med, Dept Infect Dis, Fac Med, London W12 0NN, England

[3] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[4] Macfarlane Burnett Ctr Med Res, Melbourne, Vic 3078, Australia

[5] Univ Canberra, Gadi Res Ctr Hlth & Med Sci, Div Sci & Design, Canberra, ACT 2601, Australia

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0966-842X(03)00157-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemokine-mediated movement of leukocytes from peripheral blood into tissues is essential for immunity in higher organisms. In addition, chemokines play crucial roles in controlling the development and functional aspects of leukocytes, and it is now apparent that their role is not only restricted to cell attraction. Recent in vitro and in vivo findings support the contribution of the chemokine system in the resolution of viral infections. However, the chemokine response to other viral infections can be detrimental to the host because of aberrant cellular activity. This review aims to provide insights into both sides of the chemokine spectrum, and will touch on aspects of chemokine mimicry by RNA viruses and the possible implication for disease outcome.

引用

页码：383 / 391

页数：9

共 69 条

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