Disturbances of phosphate metabolism: Another feature of metabolic syndrome

被引:53
作者
Kalaitzidis, R
Tsimihodimos, V
Bairaktari, E
Siamopoulos, KC
Elisaf, M [1 ]
机构
[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece
[2] Univ Ioannina, Sch Med, Dept Nephrol, GR-45110 Ioannina, Greece
[3] Univ Ioannina, Sch Med, Clin Chem Lab, GR-45110 Ioannina, Greece
关键词
metabolic syndrome; phosphate; magnesium;
D O I
10.1053/j.ajkd.2005.01.005
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background Despite Important recent advances In the understanding of the consequences of metabolic syndrome, its pathophysiological characteristics remain unclear. It has been proposed that disturbances in phosphate metabolism may contribute to the development of this constellation of cardiovascular risk factors. However, there have been insufficient clinical data supporting this hypothesis to date. The aim of our study is to confirm the presence of hypophosphatemia in patients with metabolic syndrome, as well as investigate mechanisms that may underlie the disturbances in phosphate metabolism In this patient group. Methods: Two hundred fifty-five individuals were enrolled. The diagnosis of metabolic syndrome was based on Adult Treatment Panel III guidelines. Subjects with fewer than 3 criteria served as controls. Results: Patients with metabolic syndrome showed significantly lower phosphate and magnesium levels compared with controls. Because fractional excretion of phosphate was similar in both groups, we assume that hypophosphatemia In patients with metabolic syndrome can be attributed to decreased dietary intake, as well as internal redistribution of this element. Lower magnesium values In the patient group may result from the same mechanisms as lower phosphate levels. In addition, hyperinsulinemia-induced renal magnesium wasting also may be a contributory factor. Conclusion: Patients with metabolic syndrome show significantly lower phosphate and magnesium levels compared with healthy individuals. The clinical significance of these disturbances, as well as their importance as targets for preventive or therapeutic interventions, remains to be established.
引用
收藏
页码:851 / 858
页数:8
相关论文
共 32 条
  • [1] LARGE PHOSPHATE SHIFTS WITH TREATMENT FOR HYPERGLYCEMIA
    BOHANNON, NJV
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1989, 149 (06) : 1423 - 1425
  • [2] Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity - Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    Bonora, E
    Saggiani, F
    Targher, G
    Zenere, MB
    Alberiche, M
    Monauni, T
    Bonadonna, RC
    Muggeo, M
    [J]. DIABETES CARE, 2000, 23 (01) : 57 - 63
  • [3] Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome - Nested case-control study
    Brunner, EJ
    Hemingway, H
    Walker, BR
    Page, M
    Clarke, P
    Juneja, M
    Shipley, MJ
    Kumari, M
    Andrew, R
    Seckl, JR
    Papadopoulos, A
    Checkley, S
    Rumley, A
    Lowe, GDO
    Stansfeld, SA
    Marmot, MG
    [J]. CIRCULATION, 2002, 106 (21) : 2659 - 2665
  • [4] Insulin sensitivity is inversely correlated with plasma intact parathyroid hormone level
    Chiu, KC
    Chuang, LM
    Lee, NP
    Ryu, JM
    McGullam, JL
    Tsai, GP
    Saad, MF
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (11): : 1501 - 1505
  • [5] Chiu KC, 2004, AM J CLIN NUTR, V79, P820
  • [6] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    Cleeman, JI
    Grundy, SM
    Becker, D
    Clark, LT
    Cooper, RS
    Denke, MA
    Howard, WJ
    Hunninghake, DB
    Illingworth, DR
    Luepker, RV
    McBride, P
    McKenney, JM
    Pasternak, RC
    Stone, NJ
    Van Horn, L
    Brewer, HB
    Ernst, ND
    Gordon, D
    Levy, D
    Rifkind, B
    Rossouw, JE
    Savage, P
    Haffner, SM
    Orloff, DG
    Proschan, MA
    Schwartz, JS
    Sempos, CT
    Shero, ST
    Murray, EZ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19): : 2486 - 2497
  • [7] HYPOPHOSPHATEMIA AND GLUCOSE-INTOLERANCE - EVIDENCE FOR TISSUE INSENSITIVITY TO INSULIN
    DEFRONZO, RA
    LANG, R
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1980, 303 (22) : 1259 - 1263
  • [8] INSULIN INCREASES RENAL MAGNESIUM EXCRETION - A POSSIBLE CAUSE OF MAGNESIUM DEPLETION IN HYPERINSULINEMIC STATES
    DJURHUUS, MS
    SKOTT, P
    HOTHERNIELSEN, O
    KLITGAARD, NAH
    BECKNIELSEN, H
    [J]. DIABETIC MEDICINE, 1995, 12 (08) : 664 - 669
  • [9] Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas
    Emoto, M
    Nishizawa, Y
    Maekawa, K
    Hiura, Y
    Kanda, H
    Kawagishi, T
    Shoji, T
    Okuno, Y
    Morii, H
    [J]. DIABETES CARE, 1999, 22 (05) : 818 - 822
  • [10] Prevalence of the metabolic syndrome among US adults - Findings from the Third National Health and Nutrition Examination Survey
    Ford, ES
    Giles, WH
    Dietz, WH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (03): : 356 - 359