Mammalian Toll-like receptors: to immunity and beyond

被引：174

作者：

Hopkins, PA ^{[1
]}

Sriskandan, S ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Infect Dis, Div Invest Sci,Gram Posit Mol Pathogenesis Grp, London W12 0NN, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2005年 / 140卷 / 03期

关键词：

IL-1; receptor; innate immunity; proinflammatory; Toll-like receptor;

D O I：

10.1111/j.1365-2249.2005.02801.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their sophisticated biology underpins the ability of innate immunity to discriminate between highly diverse microbial pathogens and self. However, the remarkable progress made in describing this biology has also revealed new immunological systems and processes previously hidden to investigators. In particular, TLRs appear to have a fundamental role in the generation of clonal adaptive immune responses, non-infectious disease pathogenesis and even in the maintenance of normal mammalian homeostasis. Although an understanding of TLRs has answered some fundamental questions at the host-pathogen interface, further issues, particularly regarding therapeutic modulation of these receptors, have yet to be resolved.

引用

页码：395 / 407

页数：13

共 175 条

[1] Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression [J].