International AIDS Society global scientific strategy: towards an HIV cure 2016

被引：353

作者：

Deeks, Steven G. ^{[1
]}

Lewin, Sharon R. ^{[2
,3
,4
,5
]}

Ross, Anna Laura ^{[6
]}

Ananworanich, Jintanat ^{[7
,8
]}

Benkirane, Monsef ^{[9
]}

Cannon, Paula ^{[10
]}

Chomont, Nicolas ^{[11
,12
]}

Douek, Daniel ^{[13
]}

Lifson, Jeffrey D. ^{[14
]}

Lo, Ying-Ru ^{[15
]}

Kuritzkes, Daniel ^{[16
]}

Margolis, David ^{[17
]}

Mellors, John ^{[18
]}

Persaud, Deborah ^{[19
,20
]}

Tucker, Joseph D. ^{[21
]}

Barre-Sinoussi, Francoise ^{[22
]}

Alter, Galit ^{[23
]}

Auerbach, Judith ^{[1
]}

Autran, Brigitte ^{[24
,25
,26
]}

Barouch, Dan H. ^{[23
,27
]}

Behrens, Georg ^{[28
]}

Cavazzana, Marina ^{[29
]}

Chen, Zhiwei ^{[30
]}

Cohen, Eric A. ^{[31
]}

Corbelli, Giulio Maria ^{[32
]}

Eholie, Serge ^{[33
]}

Eyal, Nir ^{[34
]}

Fidler, Sarah ^{[35
]}

Garcia, Laurindo ^{[36
]}

Grossman, Cynthia ^{[37
]}

Henderson, Gail ^{[17
]}

Henrich, Timothy J. ^{[1
,16
]}

Jefferys, Richard ^{[38
]}

Kiem, Hans-Peter ^{[39
]}

McCune, Joseph ^{[1
]}

Moodley, Keymanthri ^{[40
]}

Newman, Peter A. ^{[41
]}

Nijhuis, Monique ^{[42
]}

Nsubuga, Moses Supercharger ^{[43
]}

Ott, Melanie ^{[44
]}

Palmer, Sarah ^{[45
]}

Richman, Douglas ^{[46
,47
]}

Saez-Cirion, Asier ^{[48
]}

Sharp, Matthew ^{[49
]}

Siliciano, Janet ^{[50
]}

Silvestri, Guido ^{[51
]}

Singh, Jerome ^{[52
]}

Spire, Bruno ^{[53
]}

Taylor, Jeffrey ^{[54
]}

Tolstrup, Martin ^{[55
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[3] Royal Melbourne Hosp, Melbourne, Vic, Australia

[4] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia

[5] Monash Univ, Melbourne, Vic, Australia

[6] ANRS, Int & Sci Relat Off, Paris, France

[7] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA

[8] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA

[9] Univ Montpellier, CNRS UPR 1142, Inst Human Genet, Mol Virol Lab, Montpellier, France

[10] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[11] Univ Montreal, Fac Med, CRCHUM, Montreal, PQ, Canada

[12] Univ Montreal, Fac Med, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada

[13] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[14] Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick Natl Lab, Frederick, MD 21702 USA

[15] World Hlth Org Reg Off Western Pacific, Manila, Philippines

[16] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[17] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA

[18] Univ Pittsburgh, Dept Med, Div Infect Dis, 930 Scaife Hall, Pittsburgh, PA 15260 USA

[19] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

[20] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[21] Univ North Carolina Project China, Guangzhou, Guangdong, Peoples R China

[22] Inst Pasteur, Paris, France

[23] MIT & Harvard, Ragon Inst MGH, Boston, MA USA

[24] Univ Paris 06, Sorbonne Univ, CIMI, Paris, France

[25] CIMI Paris, INSERM, U1135, Paris, France

[26] Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris, France

[27] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[28] Hannover Med Sch, Clin Immunol & Rhematol, Hannover, Germany

[29] Hop Necker Enfants Malad, Ctr Invest Clin Biotherapie, Paris, France

[30] Univ Hong Kong, AIDS Inst, Pok Fu Lam, Hong Kong, Peoples R China

[31] Univ Montreal, Inst Rech Clin Montreal, Montreal, PQ, Canada

[32] European AIDS Treatment Grp, Rome, Italy

[33] Ctr Hosp Univ Treichville, Programme PAC CI, Abidjan, Cote Ivoire

[34] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA

[35] Imperial Coll London, Dept Med, London, England

[36] B Change Grp, Manila, Philippines

[37] NIMH, NIH, Bethesda, MD 20892 USA

[38] Treatment Act Grp, New York, NY 10016 USA

[39] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA

[40] Univ Stellenbosch, Dept Med, Ctr Med Eth & Law, Western Cape, South Africa

[41] Univ Toronto, Factor Inwentash Fac Social Work, Toronto, ON, Canada

[42] Univ Med Ctr Utrecht, Dept Med Microbiol, Virol, Utrecht, Netherlands

[43] Joint Clin Res Ctr, Kampala, Uganda

[44] Univ Calif San Francisco, Gladstone Inst, San Francisco, CA 94143 USA

[45] Univ Sydney, Westmead Millennium Inst Med Res, Sydney, NSW, Australia

[46] Virginia San Diego Healthcare Syst, San Diego, CA 92161 USA

[47] Univ Calif San Diego, San Diego, CA 92103 USA

[48] Inst Pasteur, Paris, France

[49] Independent HIV Educ & Advocacy Consultant, San Francisco, CA USA

[50] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

来源：

NATURE MEDICINE | 2016年 / 22卷 / 08期

关键词：

CD4(+) T-CELLS; SUPPRESSIVE ANTIRETROVIRAL THERAPY; BROADLY NEUTRALIZING ANTIBODIES; HISTONE DEACETYLASE INHIBITOR; HIGHLY PATHOGENIC SIV; LATENT HIV-1; VIRAL RESERVOIR; IN-VIVO; RALTEGRAVIR INTENSIFICATION; STAKEHOLDER ENGAGEMENT;

D O I：

10.1038/nm.4108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy.

引用

页码：839 / 850

页数：12

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