Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling

被引：86

作者：

Jun, JE

Goodnow, CC ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Genet Lab, Australian Canc Res Fdn, Canberra, ACT 2601, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, Canberra, ACT 2601, Australia

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ni1001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocyte antigen receptors are responsible for inducing the opposite responses of immunity or tolerance. How the correct polarity of antigen receptor signaling is encoded has been an enduring enigma. Here we summarize recent advances defining key scaffolding molecules, CARMA1 (also known as CARD11) and the Cbl family of ubiquitin ligases, required for either immunogenic or tolerogenic signaling by antigen receptors. These scaffolding proteins may determine the polarity of response to antigen by promoting assembly around antigen receptors of competing multiprotein signal complexes: immunosomes versus tolerosomes. Each of the factors that influence immunogenicity or tolerogenicity-stage of lymphocyte differentiation, concurrent engagement of inhibitory or costimulatory receptors, extent of receptor crosslinking, and prior antigen experience-may be integrated in lymphocytes through their capacity to influence the probability of assembling immunosomes versus tolerosomes.

引用

页码：1057 / 1064

页数：8

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