Functional characterization of a peroxisome proliferator response-element located in the intron 3 of rat peroxisomal thiolase B gene

被引：27

作者：

Hansmannel, F

Clémencet, MC

Le Jossic-Corcos, C

Osumi, T

Latruffe, N

Nicolas-Francés, V

机构：

[1] Univ Bourgogne, LBMC, GDR 2583, CNRS, F-21000 Dijon, France

[2] Himeji Inst Technol, Grad Sch Sci, Dept Life Sci, Kamigori, Hyogo 6781297, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 311卷 / 01期

基金：

日本学术振兴会;

关键词：

peroxisome; fatty acid beta oxidation; thiolase; peroxisome proliferator activated receptor alpha;

D O I：

10.1016/j.bbrc.2003.09.185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the rat peroxisomal 3-ketoacyl-CoA thiolase gene B is induced by peroxisome proliferators. Although a sequence element like a peroxisome proliferator-activated receptor (PPAR)-binding site is located in the promoter region of this gene, we previously found that this element is competent for the activation by hepatocyte nuclear factor-4, but not functional with PPARalpha. We describe here a new peroxisome proliferator-response element located in the intron 3 (+1422/+1434) that binds in vitro the PPARalpha/retinoid X receptor a heterodimer and confers the induction by PPARalpha in transfection assays. We propose a model of regulation of the rat thiolase B gene involving those elements in the promoter and intron 3. (C) 2003 Elsevier Inc. All rights reserved.

引用

收藏

页码：149 / 155

页数：7

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