Tandem conjugate reduction-aldol cyclization using Stryker's reagent

被引：83

作者：

Chiu, P ^{[1
]}

Szeto, CP ^{[1
]}

Geng, Z ^{[1
]}

Cheng, KF ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 12期

关键词：

D O I：

10.1021/ol015944n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Conjugate reduction by Stryker's reagent to form copper enolates, followed by intramolecular aldol cyclization, successfully generated five-and six-membered carbocycles in one pot efficiently. This tandem reaction is generally diastereoselective and provides good yields of the beta -hydroxyketones without any dehydration at low temperatures.

引用

页码：1901 / 1903

页数：3

共 32 条

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