Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines

被引：31

作者：

Thilo, Florian ^{[1
]}

Scholze, Alexandra ^{[1
]}

Liu, Dao Yan ^{[1
]}

Zidek, Walter ^{[1
]}

Tepel, Martin ^{[1
]}

机构：

[1] Med Klin Nephrol, D-12200 Berlin, Germany

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 471卷 / 01期

关键词：

transient receptor potential channel; proinflammatory cytokines; hypertension;

D O I：

10.1016/j.abb.2007.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes. Using quantitative RT-PCR we studied the expression of TRPC3, interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) in monocytes from 15 patients with essential hypertension and 16 age- and sex-matched normotensive control subjects. We observed an approximately 8-fold increase of TRPC3 transcripts in monocytes from patients with essential hypertension compared to normotensive control subjects (p < 0.05). We found an approximately 3-fold increase of IL-1 beta, and an approximately 9-fold increase of TNF-alpha in patients with essential hypertension compared to normotensive control subjects (each p < 0.05). We observed a significant correlation between TRPC3 transcripts with systolic blood pressure, expression of IL-1 beta P, and TNF-alpha. Using quantitative RT-PCR we observed an association of TRPC3 transcripts and proinflammatory cytokines in monocytes. (c) 2007 Elsevier Inc. All rights reserved.

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收藏

页码：57 / 62

页数：6

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