Plasma tumor necrosis factor-α, its soluble receptors and interleukin-1β levels in critically burned patients

被引：27

作者：

Zhang, B ^{[1
]}

Huang, YH ^{[1
]}

Chen, Y ^{[1
]}

Yang, Y ^{[1
]}

Hao, ZL ^{[1
]}

Xie, SL ^{[1
]}

机构：

[1] Shenyang Med Coll, Cent Hosp, Burn Ctr, Shenyang 110024, Peoples R China

来源：

BURNS | 1998年 / 24卷 / 07期

关键词：

tumor necrosis factor-alpha; interleukin-1; beta; soluble TNF receptor; burns; sepsis; multiple organ dysfunction syndrome;

D O I：

10.1016/S0305-4179(98)00091-6

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Levels of plasma TNF-alpha, interleukin-1 beta (IL-1 beta), soluble TNF-receptor I (sTNF-R I) and soluble TNF-receptor II (sTNF-R II) were determined in 16 critically burned patients. Seven of the 16 patients showed hypovolemic shock (shock group), 9 with sepsis (sepsis group), 8 with multiple organ dysfunction syndrome (MODS group) and 6 of them died (non-survival group). plasma TNF-alpha, sTNF-R I and R II were significantly higher in the shock group, the MODS group and the non-survival group than each of the control groups. TNF-alpha and sTNF-Rs increased gradually in the MODS group and the non-survival group from 1 to 5 days postburn. TNF-alpha, sTNF-R I and R II correlated positively with Goris' multiple organ failure score. Molecular sTNF-Rs/TNF-alpha ratios were lower in the sepsis group than in the non-sepsis group. These results suggest that circulating TNF and soluble TNF receptors system play an important role in the development of burn shock and MODS; high molecular ratios of endogenous sTNF-Rs might not reduce the morbidity of MODS and the mortality in critically burned patients. (C) 1998 Elsevier Science Ltd for ISBI. All rights reserved.

引用

页码：599 / 603

页数：5

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