Inflammatory and Other Biomarkers: Role in Pathophysiology and Prediction of Gestational Diabetes Mellitus

被引：192

作者：

Abell, Sally K. ^{[1
,2
]}

De Courten, Barbora ^{[1
,2
]}

Boyle, Jacqueline A. ^{[1
,2
,3
]}

Teede, Helena J. ^{[1
,2
]}

机构：

[1] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Clayton, Vic 3168, Australia

[2] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic 3168, Australia

[3] Monash Hlth, Monash Womens Serv, Clayton, Vic 3168, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 06期

基金：

英国医学研究理事会;

关键词：

NECROSIS-FACTOR-ALPHA; ACID-BINDING PROTEIN; PLASMA ADIPONECTIN CONCENTRATIONS; INCREASED INSULIN-RESISTANCE; VITAMIN-D SUPPLEMENTATION; SERUM VASPIN LEVELS; BETA-CELL FUNCTION; EARLY-PREGNANCY; ADIPOSE-TISSUE; WEIGHT-GAIN;

D O I：

10.3390/ijms160613442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Understanding pathophysiology and identifying mothers at risk of major pregnancy complications is vital to effective prevention and optimal management. However, in current antenatal care, understanding of pathophysiology of complications is limited. In gestational diabetes mellitus (GDM), risk prediction is mostly based on maternal history and clinical risk factors and may not optimally identify high risk pregnancies. Hence, universal screening is widely recommended. Here, we will explore the literature on GDM and biomarkers including inflammatory markers, adipokines, endothelial function and lipids to advance understanding of pathophysiology and explore risk prediction, with a goal to guide prevention and treatment of GDM.

引用

页码：13442 / 13473

页数：32

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