Excitatory synapses - Is bigger better?

被引：3

作者：

Malenka, RC ^{[1
]}

Nicoll, RA

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Cellular & Mol Physiol, San Francisco, CA 94143 USA

来源：

NATURE | 1998年 / 396卷 / 6710期

关键词：

D O I：

10.1038/24734

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is plenty of indirect evidence that the postsynaptic density (PSD)-95 protein is involved in the clustering and, perhaps, targeting of postsynaptic proteins. Direct evidence was lacking, but PSD-95 knockout mice have now arrived, and their properties support a clustering function. However, knocking out PSD-95 also disrupts synaptic plasticity, and this could mean that PSD-95 acts as a kind of scaffold protein.

引用

页码：414 / 415

页数：2

共 13 条

[1] A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain [J].

Butz, S ;

Okamoto, M ;

Südhof, TC .

CELL, 1998, 94 (06) :773-782

[2] THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN [J].

CHO, KO ;

HUNT, CA ;

KENNEDY, MB .

NEURON, 1992, 9 (05) :929-942

[3] PDZ proteins organize synaptic signaling pathways [J].

Craven, SE ;

Bredt, DS .

CELL, 1998, 93 (04) :495-498

[4] Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins [J].

Kim, E ;

Cho, KO ;

Rothschild, A ;

Sheng, M .

NEURON, 1996, 17 (01) :103-113

[5]

KISTNER U, 1993, J BIOL CHEM, V268, P4580

[6] Interaction of ion channels and receptors with PDZ domain proteins [J].

Kornau, HC ;

Seeburg, PH ;

Kennedy, MB .

CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) :368-373

[7]

KORNAU HC, 1995, SCIENCE, V269, P737

[8] SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS - LTP AND LTD [J].

MALENKA, RC .

CELL, 1994, 78 (04) :535-538

[9] Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein [J].

Migaud, M ;

Charlesworth, P ;

Dempster, M ;

Webster, LC ;

Watabe, AM ;

Makhinson, M ;

He, Y ;

Ramsay, MF ;

Morris, RGM ;

Morrison, JH ;

O'Dell, TJ ;

Grant, SGN .

NATURE, 1998, 396 (6710) :433-439

[10]

Rao A, 1998, J NEUROSCI, V18, P1217

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