Knockout mouse model and gametogenic failure

被引：32

作者：

Grootegoed, JA

Baarends, WM

Roest, HP

Hoeijmakers, JHJ

机构：

[1] Erasmus Univ, Fac Med & Hlth Sci, Dept Endocrinol & Reprod, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus Univ, Fac Med & Hlth Sci, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1998年 / 145卷 / 1-2期

关键词：

spermatogenesis; oogenesis; ovary; testis; infertility; ubiquitin; knockout;

D O I：

10.1016/S0303-7207(98)00183-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility. The focus will be on the mHR6B gene knockout mouse, which shows male infertility. The mHR6B gene encodes an ubiquitin-conjugating enzyme, and the data point to an important role of the ubiquitin pathway in gametogenesis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 166

页数：6

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