Tumor Microenvironment and Progression

被引：171

作者：

Dvorak, Harold F. ^{[1
]}

Weaver, Valerie M. ^{[2
]}

Tlsty, Thea D. ^{[3
]}

Bergers, Gabriele ^{[4
]}

机构：

[1] Harvard Univ, Dept Pathol, Sch Med, Ctr Vasc Biol Res,Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Univ Calif San Francisco, Dept Surg & Anat, Ctr Bioengn & Tissue Regenerat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Neurol Surg & Anat, San Francisco, CA 94143 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 103卷 / 06期

基金：

美国国家卫生研究院;

关键词：

angiogenesis; mechano-biology; patterning; HUMAN MAMMARY EPITHELIA; MESENCHYMAL TRANSITION; VESSEL FORMATION; BLOOD-VESSELS; GROWTH-FACTOR; VEGF-A; ANGIOGENESIS; CANCER; METHYLATION; INVASION;

D O I：

10.1002/jso.21709

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor-A (VEGF-A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis. Also, breast cancers arise as the result of epigenetic as well as genetic changes. Tumor blood vessel pericytes result, in part, from bone marrow precursor cells, and VEGF is a negative regulator of glioblastoma tumor cell invasion. J. Surg. Oncol. 2011;103:468-474. (C) 2011 Wiley-Liss, Inc.

引用

收藏

页码：468 / 474

页数：7

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