East meets West: an herbal tea finds a receptor

被引：33

作者：

Lazar, MA

机构：

[1] Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Genet, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Penn Diabet Ctr, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 01期

关键词：

D O I：

10.1172/JCI200420661

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

jaundice, which is caused by accumulation of bilirubin, is extremely common in newborn infants. Phototherapy is an effective treatment, but a drug therapy would also be desirable. A Chinese herbal remedy for jaundice called Yin Zhi Huang is now shown to activate a liver receptor that enhances the clearance of bilirubin (see the related article beginning on page 137). This discovery could lead to improved pharmaceutical treatments for neonatal jaundice.

引用

收藏

页码：23 / 25

页数：3

相关论文

共 27 条

[1]

Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy [J].

Beck, V ;

Unterrieder, E ;

Krenn, L ;

Kubelka, W ;

Jungbauer, A .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 84 (2-3) :259-268

[2]

Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's [J].

Bhavnani, BR .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 85 (2-5) :473-482

[3]

CAREY J, 2003, BUSINESSWEEK ON 0428

[4]

Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng [J].

Chan, RYK ;

Chen, WF ;

Dong, A ;

Guo, D ;

Wong, MS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (08) :3691-3695

[5]

Nuclear receptors and lipid physiology: Opening the X-files [J].

Chawla, A ;

Repa, JJ ;

Evans, RM ;

Mangelsdorf, DJ .

SCIENCE, 2001, 294 (5548) :1866-1870

[6]

Drug therapy: Neonatal hyperbilirubinemia. [J].

Dennery, PA ;

Seidman, DS ;

Stevenson, DK .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (08) :581-590

[7]

Advising patients who seek alternative medical therapies [J].

Eisenberg, DM .

ANNALS OF INTERNAL MEDICINE, 1997, 127 (01) :61-69

[8]

A tailored therapy for the metabolic syndrome -: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models [J].

Etgen, GJ ;

Oldham, BA ;

Johnson, WT ;

Broderick, CL ;

Montrose, CR ;

Brozinick, JT ;

Misener, EA ;

Bean, JS ;

Bensch, WR ;

Brooks, DA ;

Shuker, AJ ;

Rito, CJ ;

McCarthy, JR ;

Ardecky, RJ ;

Tyhonas, JS ;

Dana, SL ;

Bilakovics, JM ;

Paterniti, JR ;

Ogilvie, KM ;

Liu, S ;

Kauffman, RF .

DIABETES, 2002, 51 (04) :1083-1087

[9]

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan [J].

Howitz, KT ;

Bitterman, KJ ;

Cohen, HY ;

Lamming, DW ;

Lavu, S ;

Wood, JG ;

Zipkin, RE ;

Chung, P ;

Kisielewski, A ;

Zhang, LL ;

Scherer, B ;

Sinclair, DA .

NATURE, 2003, 425 (6954) :191-196

[10]

Prevention and management of prostate cancer using PC-SPES: A scientific perspective [J].

Hsieh, TC ;

Lu, XH ;

Chea, J ;

Wu, JM .

JOURNAL OF NUTRITION, 2002, 132 (11) :3513S-3517S