Prefrontal cortex-nucleus accumbens interaction:: In vivo modulation by dopamine and glutamate in the prefrontal cortex

被引:125
作者
Del Arco, Alberto [1 ]
Mora, Francisco [1 ]
机构
[1] Univ Complutense, Dept Physiol, Fac Med, E-28040 Madrid, Spain
关键词
prefrontal cortex; nucleus accumbens; glutamate; dopamine; acetylcholine; D2; receptors; NMDA receptors; microdialysis; locomotion; schizophrenia; environmental enrichment; rat;
D O I
10.1016/j.pbb.2008.04.011
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Previous experimental studies have shown that the prefrontal cortex (PFC) regulates the activity of the nucleus accumbens (NAc), and in particular the release of dopamine in this area of the brain. In the present report we review recent microinjections/microdialysis studies from our laboratory on the effects of stimulation/blockade of cloparnine and glutamate receptors in the PFC that modulate dopamine, and also acetylcholine release in the NAc. Stimulation of prefrontal D2 dopamine receptors, but not group I mGlu glutamate receptors, reduces the release of dopamine and acetylcholine in the NAc and spontaneous motor activity. This inhibitory role of prefrontal D2 receptors is not changed by acute systemic injections of the NMDA antagonist phencyclidine. On the other hand, the blockade of NMDA receptors in the PFC increases the release of cloparnine and acetycholine in the NAc as well as motor activity which suggests that the hypofunction of prefrontal NMDA receptors is able to produce the neurochemical and behavioural changes associated with a dysfunction of the corticolimbic circuit. We suggest here that cloparnine and glutamate receptors are, in part, segregated in specific cellular circuits in the PFC. Thus, the stimulation/blockade of these receptors would have a different net impact on PFC output projections to regulate cloparnine and acetylcholine release in the NAc and in guided behaviour. Finally, it is speculated that environmental enrichment might produce plastic changes that modify the functional interaction between the PFC and the NAc in both physiological and pathological conditions. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:226 / 235
页数:10
相关论文
共 143 条
[1]   Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man [J].
Aalto, S ;
Ihalainen, J ;
Hirvonen, J ;
Kajander, J ;
Scheinin, H ;
Tanila, H ;
Någren, K ;
Vilkman, H ;
Gustafsson, LL ;
Syvälahti, E ;
Hietala, J .
PSYCHOPHARMACOLOGY, 2005, 182 (03) :375-383
[2]   Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia [J].
Abi-Dargham, A ;
Moore, H .
NEUROSCIENTIST, 2003, 9 (05) :404-416
[3]   THE EFFECT OF CHOLINERGIC STIMULATION IN THE NUCLEUS ACCUMBENS ON LOCOMOTOR BEHAVIOR [J].
AUSTIN, MC ;
KALIVAS, PW .
BRAIN RESEARCH, 1988, 441 (1-2) :209-214
[4]   Amygdala input to medial prefrontal cortex (mPFC) in the rat: A light and electron microscope study [J].
Bacon, SJ ;
Headlam, AJN ;
Gabbott, PLA ;
Smith, AD .
BRAIN RESEARCH, 1996, 720 (1-2) :211-219
[5]   Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex [J].
Baldwin, AE ;
Sadeghian, K ;
Kelley, AE .
JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :1063-1071
[6]   ENVIRONMENTAL ENRICHMENT ATTENUATES LOCOMOTOR SENSITIZATION, BUT NOT IN-VITRO DOPAMINE RELEASE, INDUCED BY AMPHETAMINE [J].
BARDO, MT ;
BOWLING, SL ;
ROWLETT, JK ;
MANDERSCHEID, P ;
BUXTON, ST ;
DWOSKIN, LP .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 51 (2-3) :397-405
[7]  
Bardo MT, 2001, PSYCHOPHARMACOLOGY, V155, P278
[8]   Dopamine depletion in the medial prefrontal cortex induces sensitized-like behavioral and neurochemical responses to cocaine [J].
Beyer, CE ;
Steketee, JD .
BRAIN RESEARCH, 1999, 833 (02) :133-141
[9]   Intra-medial prefrontal cortex injection of quinpirole, but not SKF 38393, blocks the acute motor-stimulant response to cocaine in the rat [J].
Beyer, CE ;
Steketee, JD .
PSYCHOPHARMACOLOGY, 2000, 151 (2-3) :211-218
[10]   Dopaminergic modulation of prefrontal cortical input to nucleus accumbens neurons in vivo [J].
Brady, AM ;
O'Donnell, P .
JOURNAL OF NEUROSCIENCE, 2004, 24 (05) :1040-1049