Gene expression as a drug discovery tool

被引：20

作者：

Evans, WE

Guy, RK

机构：

[1] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[2] Univ Calif San Francisco, Calif Inst Quantitat Biomed Res, Bay Area Screening Ctr, San Francisco, CA 94143 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 03期

关键词：

D O I：

10.1038/ng0304-214

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

After establishing a pattern of gene expression that identifies a desired drug effect in leukemia cells (e. g., differentiation), post-treatment gene expression can be used to screen candidate compounds for their ability to induce the target phenotype.

引用

收藏

页码：214 / 215

页数：3

相关论文

共 14 条

[1] Hit and lead generation:: Beyond high-throughput screening [J].

Bleicher, KH ;

Böhm, HJ ;

Müller, K ;

Alanine, AI .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :369-378

[2] Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells [J].

Cheok, MH ;

Yang, WL ;

Pui, CH ;

Downing, JR ;

Cheng, C ;

Naeve, CW ;

Relling, MV ;

Evans, WE .

NATURE GENETICS, 2003, 34 (01) :85-90

[3] Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray [J].

Feng, X ;

Jiang, Y ;

Meltzer, P ;

Yen, PM .

MOLECULAR ENDOCRINOLOGY, 2000, 14 (07) :947-955

[4] Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring [J].

Golub, TR ;

Slonim, DK ;

Tamayo, P ;

Huard, C ;

Gaasenbeek, M ;

Mesirov, JP ;

Coller, H ;

Loh, ML ;

Downing, JR ;

Caligiuri, MA ;

Bloomfield, CD ;

Lander, ES .

SCIENCE, 1999, 286 (5439) :531-537

[5]

Holleman Amy, 2003, Proceedings of the American Association for Cancer Research Annual Meeting, V44, P310

[6] USE OF ALL-TRANS RETINOIC ACID IN THE TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA [J].

HUANG, ME ;

YE, YC ;

CHEN, SR ;

CHAI, JR ;

LU, JX ;

ZHOA, L ;

GU, LJ ;

WANG, ZY .

BLOOD, 1988, 72 (02) :567-572

[7] Innovation - Target discovery [J].

Lindsay, MA .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (10) :831-838

[8] Drug target validation and identification of secondary drug target effects using DNA microarrays [J].

Marton, MJ ;

DeRisi, JL ;

Bennett, HA ;

Iyer, VR ;

Meyer, MR ;

Roberts, CJ ;

Stoughton, R ;

Burchard, J ;

Slade, D ;

Dai, HY ;

Bassett, DE ;

Hartwell, LH ;

Brown, PO ;

Friend, SH .

NATURE MEDICINE, 1998, 4 (11) :1293-1301

[9] Acute lymphoblastic leukemia [J].

Pui, CH ;

Evans, WE .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (09) :605-615

[10] Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation [J].

Stegmaier, K ;

Ross, KN ;

Colavito, SA ;

O'Malley, S ;

Stockwell, BR ;

Golub, TR .

NATURE GENETICS, 2004, 36 (03) :257-263