Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg

被引：133

作者：

Horwitz, David A. ^{[1
]}

Zheng, Song Guo ^{[1
]}

Wang, Juhua ^{[1
]}

Gray, J. Dixon ^{[1
]}

机构：

[1] Univ So Calif, Keck School Med, Dept Med, Div Rheumatol & Immunol, Los Angeles, CA 90033 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Foxp3; IL-2; IL-6; Regulatory cells; TGF-beta;

D O I：

10.1002/eji.200738109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+)Foxp3(+) Treg consist of two indistinguishable subsets induced in either the thymus or the periphery. In addition to their suppressive activities, IL-6 can convert natural Treg to pro-inflammatory IL-17-producing cells, but those induced with IL-2 and TGF-beta remain Treg. Unlike mouse CD4(+)CD25(-) cells, which rapidly become polyclonal Foxp3(+)CD25(+) Treg when activated appropriately with IL-2 and TGF-beta, human T cells require multiple stimulations to become similar suppressor cells.

引用

页码：912 / 915

页数：4

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