Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques:: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

被引：38

作者：

Florese, Ruth H. ^{[1
]}

Wiseman, Roger W. ^{[2
,3
]}

Venzon, David ^{[4
]}

Karl, Julie A. ^{[2
,3
]}

Demberg, Thorsten ^{[1
]}

Larsen, Kay ^{[5
]}

Flanary, Leon ^{[5
]}

Kalyanaraman, V. S. ^{[6
]}

Pal, Ranajit ^{[6
]}

Titti, Fausto ^{[7
]}

Patterson, L. Jean ^{[1
]}

Heath, Megan J. ^{[1
]}

O'Connor, David H. ^{[1
]}

Cafaro, Aurelio ^{[7
]}

Ensoli, Barbara ^{[7
]}

Robert-Guroff, Marjorie ^{[1
]}

机构：

[1] NCI, NIH, Vaccine Branch, Bethesda, MD 20892 USA

[2] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53706 USA

[4] NCI, NIH, Biostat & Data Management Sect, Bethesda, MD 20892 USA

[5] Washington Natl Primate Res Ctr, Seattle, WA 98109 USA

[6] Adv BioSci Labs Inc, Kensington, MD 20895 USA

[7] Ist Super Sanita, Natl AIDS Ctr, I-00161 Rome, Italy

来源：

VACCINE | 2008年 / 26卷 / 26期

关键词：

HIV Tat vaccines; Mauritian cynomolgus macaques; Indian rhesus macaques; MHC haplotypes; host susceptibility/resistance factors;

D O I：

10.1016/j.vaccine.2008.03.100

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regimen modestly reduced acute viremia in rhesus macaques after SHIV89.6P challenge. Confounding variables uncovered in Mauritian macaques included significant associations of susceptibility to infection with MHC class IB and class II H2 and H5 haplotypes, and resistance to infection with class IB haplotypes H3 and H6. Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored. Published by Elsevier Ltd.

引用

页码：3312 / 3321

页数：10

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