Genetics of Dementia

被引：43

作者：

Paulson, Henry L. ^{[1
,2
]}

Igo, Indu ^{[1
]}

机构：

[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Alzheimers Dis Ctr, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN NEUROLOGY | 2011年 / 31卷 / 05期

关键词：

Amyloid; frontotemporal dementia; dementia with Lewy bodies; neurodegeneration; genetic risk factors; FRONTOTEMPORAL LOBAR DEGENERATION; GENOME-WIDE ASSOCIATION; AMYLOID-BETA-PROTEIN; AMYOTROPHIC-LATERAL-SCLEROSIS; CASSETTE TRANSPORTER A7; ALZHEIMERS-DISEASE; PROGRANULIN MUTATIONS; HEXANUCLEOTIDE REPEAT; HUNTINGTONS-DISEASE; IDENTIFIES VARIANTS;

D O I：

10.1055/s-0031-1299784

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic factors are now recognized to play an important role in most age-related dementias. Although other factors, including aging itself, contribute to dementia, in this review the authors focus on the role of specific disease-causing genes and genetic factors in the most common age-related dementias. They review each dementia within the context of a genes/environment continuum, with varying levels of genetic versus environmental influence. All major classes of dementia will be discussed but greatest attention will be given to the most common dementia, Alzheimer's disease, for which several new genetic factors were recently identified.

引用

页码：449 / 460

页数：12

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