SK channels in excitability, pacemaking and synaptic integration

被引：156

作者：

Bond, CT

Maylie, J

Adelman, JP ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.conb.2005.05.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Small conductance calcium-activated potassium channels link elevations of intracellular calcium ions to membrane potential, exerting a hyperpolarizing influence when activated. The consequences of SK channel activity have been revealed by the specific blocker apamin, a pepticle toxin from honeybee venom. Recent studies have revealed unexpected roles for SK channels in fine-tuning intrinsic cell firing properties and in responsiveness to synaptic input. They have also identified specific roles for different SK channel subtypes. A host of Ca2+ sources, including distinct subtypes of voltage-dependent calcium channels, intracellular Ca2+ stores and Ca2+- permeable ionotropic neurotransmitter receptors, activate SK channels. The macromolecular complex in which the Ca2+ source, SK channels and various modulators are assembled determines the kinetics and consequences of SK channel activation.

引用

收藏

页码：305 / 311

页数：7

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