Neurotransmitter receptor trafficking and the regulation of synaptic strength

被引：31

作者：

Kittler, JT

Moss, SJ

机构：

[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

[2] UCL, Dept Pharmacol, London WC1E 6BT, England

来源：

TRAFFIC | 2001年 / 2卷 / 07期

关键词：

excitatory; inhibitory; synapse; AMPA; NMDA; GABA; glutamate; endocytosis; receptor sorting; dynamin; NSF; GABARAP; GRIP; PICK; LTP; LTD; adaptin; clathrin;

D O I：

10.1034/j.1600-0854.2001.20702.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Modulation of the strength of synapses is thought to be one of the mechanisms that underlies learning and memory and is also likely to be important in processes of neuropathology and drug tolerance. This review focuses on the emerging role of postsynaptic neurotransmitter receptor trafficking as an essential mechanism underlying the dynamic regulation of synaptic strength.

引用

页码：437 / 448

页数：12

共 119 条

[1] Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase [J].