Mutation and recombination in Helicobacter pylori:: Mechanisms and role in generating strain diversity

被引：69

作者：

Kraft, C ^{[1
]}

Suerbaum, S ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Med Microbiol & Hosp Epidemiol, D-30625 Hannover, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2005年 / 295卷 / 05期

关键词：

Helicobacter pylori; mutation; competence; recombination; repair;

D O I：

10.1016/j.ijmm.2005.06.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The pathogenic bacterium Helicobacter pylori infects half of the human population and it is one of the most genetically diverse bacterial species known. The unusual combination of high frequencies of mutation and recombination events together with a very small size of DNA fragments imported into the genome after recombination, contribute to its genetic variability. In this review article, we discuss the genetic variability of H. pylori, the mechanisms that generate diversity, and the potential relevance of genetic variability to colonization and pathogenicity. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：299 / 305

页数：7

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