Off to a good start: The influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health

被引：61

作者：

Chapin, RE

Robbins, WA

Schieve, LA

Sweeney, AM

Tabacova, SA

Tomashek, KM

机构：

[1] Pfizer R&D, Groton, CT 06340 USA

[2] Univ Calif Los Angeles, Ctr Environm & Occupat Hlth, Los Angeles, CA USA

[3] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA

[4] Texas A&M Univ, Syst Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, College Stn, TX 77843 USA

[5] US FDA, Natl Ctr Toxicol Res, Rockville, MD 20857 USA

[6] Ctr Dis Control & Prevent, Maternal & Infant Hlth Branch, Atlanta, GA USA

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2004年 / 112卷 / 01期

关键词：

birth defects; chemical exposure; conception; fertilization; review;

D O I：

10.1289/ehp.6261

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The scientific community is developing a compelling body of evidence that shows the importance of the in utero environment (including chemical and hormonal levels) to the ultimate health of the child and even of the aging adult. This article summarizes the evidence that shows this impact begins with conception. Only a full life-cycle evaluation will help us understand these impacts, and only such an understanding will produce logically prioritized mitigation strategies to address the greatest threats first. Clearly, the time for analysis begins when the next generation is but a twinkle in the eye.

引用

页码：69 / 78

页数：10

共 224 条

[1]

Agency for Toxic Substances & Disease Registry (ATSDR), 2000, TOX PROF POL BIPH PC

[2] MONOZYGOTIC TWINNING IN THE HUMAN IS ASSOCIATED WITH THE ZONA-PELLUCIDA ARCHITECTURE [J].