5-hydroxytryptamine (serotonin): Biphasic dose responses

被引：16

作者：

Calabrese, EJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2001年 / 31卷 / 4-5期

关键词：

5-hydroxytryptamine; 5-HT; serotonin; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;

D O I：

10.1080/20014091111820

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This article briefly summarizes the occurrence of biphasic dose-response relationships associated with 5-hydroxytryptamine (5-HT) receptor systems, as well as 5-HT agonists and antagonists. Such biphasic responses have been reliably reported in multiple experimental settings that explored a broad range of responses, including aggressive behavior, cardiovascular functioning, muscle relaxation, and interactions with other receptor systems such as adrenergic interaction as well as with neurotransmitters such as NMDA.

引用

页码：553 / 561

页数：9

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