Etanercept-Induced Lupus Accompanied by Hemophagocytic Syndrome

被引：14

作者：

Araki, Daisuke ^{[1
]}

Fujii, Hiroshi ^{[1
]}

Matsumura, Masami ^{[2
]}

Yamagishi, Masakazu ^{[3
]}

Yachie, Akihiro ^{[4
]}

Kawano, Mitsuhiro ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med, Dept Internal Med, Div Rheumatol, Kanazawa, Ishikawa 9201192, Japan

[2] Kanazawa Univ, Grad Sch Med, Res Ctr Med Educ, Kanazawa, Ishikawa 9201192, Japan

[3] Kanazawa Univ, Grad Sch Med, Dept Internal Med, Div Cardiol, Kanazawa, Ishikawa 9201192, Japan

[4] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Med, Dept Pediat, Kanazawa, Ishikawa 9201192, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 17期

关键词：

hemophagocytic syndrome; drug-induced lupus; TNF-alpha inhibitor; rheumatoid arthritis; MACROPHAGE ACTIVATION SYNDROME; DRUG-INDUCED LUPUS; RHEUMATOID-ARTHRITIS; CYTOKINE PROFILES; ERYTHEMATOSUS; PATIENT; FEATURES; ADULTS;

D O I：

10.2169/internalmedicine.50.5430

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Hemophagocytic syndrome (HPS) is a severe, potentially life-threatening disorder characterized by an excessive activation of macrophages, such as may occur in the setting of lupus. A 62-year-old Japanese woman treated with etanercept for rheumatoid arthritis developed persistent fever, cytopenia, coagulopathy, and hyperferritinemia. Simultaneously, lupus-like features including pleuritis, hypocomplementemia, and positive autoantibodies were observed. She was diagnosed with HPS related to etanercept-induced lupus, and underwent immunosuppressive therapy with successful recovery. To our knowledge, this is the first case of etanercept-induced lupus accompanied by HPS. This case suggests that HPS should be considered as a complication during TNF-alpha inhibitor therapy.

引用

页码：1843 / 1848

页数：6

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