'O-acyl isopeptide method' for the efficient preparation of amyloid β peptide 1-42 mutants

被引：38

作者：

Sohma, Y ^{[1
]}

Chiyomori, Y ^{[1
]}

Kimura, M ^{[1
]}

Fukao, F ^{[1
]}

Taniguchi, A ^{[1
]}

Hayashi, Y ^{[1
]}

Kimura, T ^{[1
]}

Kiso, Y ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Ctr Frontier Res Med Sci, Century COE Program 21st, Dept Med Chem,Yamashina Ku, Kyoto 6078412, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 22期

基金：

日本学术振兴会;

关键词：

O-acyl isopeptide method; Alzheimer's disease; A beta 1-42; A beta 1-42 mutant; 26-AIA beta 42; O-N intramolecular acyl migration reaction;

D O I：

10.1016/j.bmc.2005.06.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel water-soluble isopeptides of A beta 1-42 mutants, '26-O-acyl isoA beta 1-42 (26-AIA beta 42) mutants', which were efficiently converted to intact A beta 1-42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of A beta 1-42 mutants. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：6167 / 6174

页数：8

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