Homeobox genes and cancer

被引：189

作者：

Cillo, C

Faiella, A

Cantile, M

Boncinelli, E

机构：

[1] Ist Sci San Raffaele, Dept Biotechnol DIBIT, I-20123 Milan, Italy

[2] CNR, Inst Cellular & Mol Pharmacol, I-20133 Milan, Italy

[3] Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, I-80131 Naples, Italy

来源：

EXPERIMENTAL CELL RESEARCH | 1999年 / 248卷 / 01期

关键词：

D O I：

10.1006/excr.1999.4451

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Homeobox-containing genes are a family of regulatory genes encoding transcription factors that primarily play a crucial role during development. Several indications suggest their involvement in the control of cell growth and, when dysregulated, in oncogenesis. We will describe the implications, in tumor origin and evolution, of members of the homeobox gene families HOX, EMX, PAX, and MSX as well as of other divergent homeobox genes. We will also propose a model for the function of the HOX gene network in controlling cell identity to account for the involvement of some HOX genes in both normal development and oncogenesis. (C) 1999 Academic Press.

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页码：1 / 9

页数：9

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