Zebrafish Lipid Metabolism: From Mediating Early Patterning to the Metabolism of Dietary Fat and Cholesterol

被引：171

作者：

Anderson, Jennifer L. ^{[1
]}

Carten, Juliana D. ^{[1
]}

Farber, Steven A. ^{[1
]}

机构：

[1] Carnegie Inst Sci, Dept Embryol, Baltimore, MD USA

来源：

ZEBRAFISH: CELLULAR AND DEVELOPMENTAL BIOLOGY, PT B, THIRD EDITION | 2011年 / 101卷

关键词：

TRIGLYCERIDE TRANSFER PROTEIN; TARGETED GENE KNOCKDOWN; GERM-CELL MIGRATION; A-I GENES; DEVELOPMENTAL EXPRESSION; ABSORPTION INHIBITOR; SPECTRAL PROPERTIES; GLUCOSE-METABOLISM; BODIPY-CHOLESTEROL; LIVER DEVELOPMENT;

D O I：

10.1016/B978-0-12-387036-0.00005-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Lipids serve essential functions in cells as signaling molecules, membrane components, and sources of energy. Defects in lipid metabolism are implicated in a number of pandemic human diseases, including diabetes, obesity, and hypercholesterolemia. Many aspects of how fatty acids and cholesterol are absorbed and processed by intestinal cells remain unclear and present a hurdle to developing approaches for disease prevention and treatment. Numerous studies have shown that the zebrafish is an excellent model for vertebrate lipid metabolism. In this chapter, we review studies that employ zebrafish to better understand lipid signaling and metabolism.

引用

页码：111 / 141

页数：31

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