Current therapy of lupus nephritis.: Which is the best option?

被引：11

作者：

Silva-Fernandez, L. ^{[1
]}

Andreu-Sanchez, J. L. ^{[1
]}

Ginzler, E. A. ^{[2
]}

机构：

[1] Hosp Univ Puerta Hierro, Serv Reumatol, Madrid 28035, Spain

[2] Suny Downstate Med Ctr, Div Rheumatol, Brooklyn, NY 11203 USA

来源：

REVISTA CLINICA ESPANOLA | 2008年 / 208卷 / 03期

关键词：

systemic lupus erythematosus; lupus nephritis; therapy; micophenolate mofetil;

D O I：

10.1157/13115822

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Renal involvement in systemic lupus erythematosus (SLE) is an important cause of morbidity and mortality, reaching a prevalence of 39% during the course of the disease. Currently, the therapy for severe lupus nephritis is based on the use of high-dose corticosteroids and immunosuppressive drugs, being traditionally cyclophosphamide the most frequently used agent. Recent studies have demonstrated the efficacy of mycophenolate mofetil as induction therapy for lupus nephritis. Azathioprine, a safe drug during pregnancy, has not been demonstrated to be as effective as mycophenolate or cyclophosphamide as induction therapy, although it is an effective drug for maintenance of remission.

引用

页码：138 / 141

页数：4

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