Arterial thrombosis-insidious, unpredictable and deadly

被引：498

作者：

Jackson, Shaun P. ^{[1
,2
]}

机构：

[1] Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic 3004, Australia

[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

NATURE MEDICINE | 2011年 / 17卷 / 11期

基金：

英国医学研究理事会;

关键词：

ACUTE MYOCARDIAL-INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; HUMAN ATHEROSCLEROTIC PLAQUES; VON-WILLEBRAND-FACTOR; GLYCOPROTEIN-VI; PLATELET-ADHESION; TISSUE FACTOR; MICE LACKING; FACTOR-XI; IN-VIVO;

D O I：

10.1038/nm.2515

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of blood clots-thrombosis-at sites of atherosclerotic plaque rupture is a major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in identifying the pathogenic mechanisms regulating arterial thrombosis has led to the development of newer therapeutics, and there is general anticipation that these treatments will have greater efficacy and improved safety. However, major advances in this field require the identification of specific risk factors for arterial thrombosis in affected individuals and a rethink of the 'one size fits all' approach to antithrombotic therapy.

引用

页码：1423 / 1436

页数：14

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