Antagonistic control of disease resistance protein stability in the plant immune system

被引：209

作者：

Holt, BF

Belkhadir, Y

Dangl, JL

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Curriculum Genet, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA

来源：

SCIENCE | 2005年 / 309卷 / 5736期

关键词：

D O I：

10.1126/science.1109977

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance (R) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls preactivation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate preactivation R protein accumulation and signaling competence.

引用

收藏

页码：929 / 932

页数：4

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