The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer

被引：18

作者：

Birnbaum, David J. ^{[1
]}

Mamessier, Emilie ^{[1
]}

Birnbaum, Daniel ^{[1
]}

机构：

[1] Inst J Paoli I Calmettes, INSERM, UMR1068, Ctr Rech Cancerol Marseille,Lab Oncol Mol, F-13009 Marseille, France

来源：

CELL CYCLE | 2012年 / 11卷 / 04期

关键词：

ARID1A; GATA6; SWI/SNF; pancreatic cancer; gene mutation; TGF beta; signaling pathway; EPITHELIAL-MESENCHYMAL TRANSITION; SOMATIC MUTATIONS; ARID1A; METASTASIS;

D O I：

10.4161/cc.11.4.19130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Pancreatic adenocarcinoma is one of the most aggressive human cancers. It displays many different chromosomal abnormalities and mutations. To design new therapeutic strategies, it is important to identify the signaling pathways and gene networks within this apparent complexity that are predominantly altered. The TGF beta signaling pathway and associated transcription network emerges as a central actor of pancreatic oncogenesis. Its tumor suppressor function in this tissue can be affected by several alterations.

引用

页码：683 / 686

页数：4

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