Nanotechnology for biomaterials engineering: Structural characterization of amphiphilic polymeric nanoparticles by H-1 NMR spectroscopy

被引：167

作者：

Hrkach, JS ^{[1
]}

Peracchia, MT ^{[1
]}

Domb, A ^{[1
]}

Lotan, N ^{[1
]}

Langer, R ^{[1
]}

机构：

[1] MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139

来源：

BIOMATERIALS | 1997年 / 18卷 / 01期

关键词：

NMR spectroscopy; structural characterization; biodegradable nanoparticles; nanotechnology;

D O I：

10.1016/S0142-9612(96)00077-4

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nanoparticles composed of diblock poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) or a branched, multiblock PLA-(PEG)(3) were prepared by the single emulsion technique. Results of previous studies of these nanoparticles suggested that their structure is of the core-corona type with a polyester core and an outer PEG coating. In the present study, H-1 NMR spectroscopy was utilized to provide direct evidence of the structure of these nanoparticles suspended in an aqueous environment. The results confirm the existence of the core-corona structure under these conditions, and show that the PEG moieties extend out from the nanoparticle core into the aqueous environment, and exhibit chain mobility similar to that of PEG in solution. (C) 1996 Elsevier Science Limited

引用

页码：27 / 30

页数：4

共 31 条

[1] LIPOSOMES CONTAINING SYNTHETIC LIPID DERIVATIVES OF POLY(ETHYLENE GLYCOL) SHOW PROLONGED CIRCULATION HALF-LIVES INVIVO [J].