Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats

被引：49

作者：

Ariga, Hajime ^{[2
]}

Nakade, Yukionii ^{[2
]}

Tsukamoto, Kiyoshi ^{[2
]}

Imai, Kenji ^{[2
]}

Chen, Cindy ^{[2
]}

Mantyh, Christopher ^{[2
]}

Pappas, Theodore N. ^{[2
]}

Takahashi, Toku ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Surg, Durham, NC USA

来源：

REGULATORY PEPTIDES | 2008年 / 146卷 / 1-3期

关键词：

growth hormone secretagogue receptor; postprandial gastric contraction; vagus nerve;

D O I：

10.1016/j.regpep.2007.08.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin is known to enhance gastric motility and accelerate gastric emptying of liquid and solid food in rats. As solid gastric emptying is regulated by the coordinated motor pattern between the antrum and pylorus (antro-pyloric coordination), we studied the correlation between solid gastric emptying and antro-pyloric coordination in response to ghrelin. Rats were given 1.5 g of solid food after a 24-h fasting. Immediately after the ingestion, ghrelin (0.4-8.0 mu g/kg) or saline was administered by intraperitoneal (IP) injection. Ninety minutes after the feeding, rats were euthanized and gastric content was removed to calculate gastric emptying. To evaluate the antro-pyloric coordination, strain gauge transducers were sutured on the antrum and pylorus. The incidence of postprandial antro-pyloric coordination was compared between ghrelin-and saline injected rats. In saline-injected rats, gastric emptying was 58.3 +/- 3.7% (n=6). Ghrelin (4.0-8.0 mu g/kg), accelerated gastric emptying. Maximum effect was obtained by ghrelin (4.0 mu g/kg), which significantly accelerated gastric emptying to 77.4 +/- 3.7% (n=6, p < 0.05). The number of antropyloric coordination 20-40 min after feeding was significantly increased in ghrelin-injected rats, compared to that of saline-injected rats (n=4, p < 0.05). It is suggested that enhanced antro-pyloric coordination play an important role in accelerated solid gastric emptying induced by ghrelin. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：112 / 116

页数：5

共 29 条

[1] Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach [J].