Increased number of [125I] BH-substance P receptors in schizophrenia

被引：9

作者：

Rioux, L

Nissanov, J

Joyce, JN

机构：

[1] Univ Penn, Dept Psychiat, Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pharmacol, Sch Med, Philadelphia, PA 19104 USA

[3] Drexel Univ, Comp Vis Ctr Vertebrate Brain Mapping, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA USA

[4] Sun Hlth Res Inst, LJ Roberts Ctr, Sun City, AZ USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 08期

关键词：

NK1; receptors; striatum; tachykinin;

D O I：

10.1016/S0278-5846(98)00084-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1- This study used quantitative receptor autoradiography to evaluate if the hyperdopaminergic state in the striatum of schizophrenics is associated with decreased NK1 receptor density. 2- A significant increase of NK1 sites was detected in caudate and nucleus accumbens of schizophrenic patients as compared to controls. No statistical difference was observed for the putamen. 3- Neuroleptics used in the treatment of schizophrenia may be responsible for the observed increase in NK1 receptors.

引用

页码：1295 / 1299

页数：5

共 17 条

[1]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[2]

ARNOLD SE, 1995, AM J PSYCHIAT, V152, P731

[3] STRIATAL TACHYKININ BIOSYNTHESIS - REGULATION OF MESSENGER-RNA AND PEPTIDE LEVELS BY DOPAMINE AGONISTS AND ANTAGONISTS [J].